In the white-hot sun of the New Mexico desert, scientist Vera Buckley watches in fascination as a mysterious object plummets to Earth and explodes in a blinding flash, sending out a shock wave that briefly stops Vera’s heart and panics her techie coworker Alan Harris.
Drawn together by destiny, Vera, Erin, Joshua, Raul and Peter convene together where they meet the mysterious Rose. Rose reveals that they are angels and their mission is to find and stop the Four Horsemen of the Apocalypse from bringing about the Rapture. Meanwhile, The Man’s real identity is revealed and he continues to tempt Vera with clues about her missing son.
On the hunt for the Horseman of War, Joshua, Erin and Peter make great strides for the group. Raul and Vera are more hesitant to believe and when they stray, there are unforeseen consequences. But when Vera discovers her gift, she finally starts to rethink her purpose.
As the fully united Messengers work to track down the Second Horseman of the Apocalypse, Alan and Vera continue their quest to uncover the genesis stone’s secrets. Meanwhile, Erin begins to discover the price of her gift.
The Messengers struggle to stay together and on mission when an unforeseen setback causes them to question whether being an Angel is causing them more harm than good. In the process of pursuing their own desires, the Messengers discover that destiny has a strange way of bringing them back together.
The Man informs the Messengers one of their own has betrayed them and another is in imminent danger, while Amy's drawings predict the arrival of someone who could change the course of everyone's destinies.
Based on contradictory clues, the Messengers make clashing predictions about who will be the Horseman of Famine. Meanwhile, Vera almost unearths the Horsemen's master plan.
The Messengers' powers are tested as they attempt to rescue someone from government lockup. Meanwhile, Joshua has a vision foreshadowing the arrival of a deceptive new adversary.